To disable Windows Defender real-time protection: In this case, you can disable the Windows Defender real-time protection temporarily, install Sisense, and then reactivate it.
For example, when installing Sisense in Windows Server 2019, Windows Defender scans each zipped file included in the installer making the installation process a lot longer. However, in some scenarios, you may want to disable the real-time protection of Windows Defender. Windows Defender is an anti-malware engine included with Windows Server 2019 to protect your device and data against viruses, ransomware, spyware, and other security threats. Disabling Windows Defender Real-Time Protection